ADJUNCTIVE CORRECTION OF ANTIBIOTIC-ASSOCIATED INTESTINAL DYSBIOSIS IN PATIENTS WITH CHRONIC BRUCELLOSIS

Abstract

The present study evaluated alterations in intestinal microbiota composition in patients with secondary chronic forms of brucellosis and assessed the clinical effectiveness of adjunctive probiotic correction. A total of patients with chronic brucellosis were clinically monitored, and the condition of their intestinal microflora was examined during the course of combined antibacterial therapy. Particular attention was paid to dysbiotic changes developing after prolonged etiotropic treatment. The findings demonstrated that the addition of Bactisubtil to conventional therapy contributed to a more rapid improvement in clinical manifestations and facilitated restoration of intestinal microbial balance compared with standard treatment alone. Patients receiving adjunctive probiotic therapy showed earlier resolution of major clinical symptoms, indicating a beneficial role of microbiota correction in the комплекс management of chronic brucellosis. The observed differences were statistically significant (P<0.05).